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Hyaluronidase vs vtrace trial#
Hyaluronidase vs vtrace plus#

Common applications are ophthalmic surgery, in combination with local anesthetics. It is, therefore, used in medicine in conjunction with other drugs to speed their dispersion and delivery. īy catalyzing the hydrolysis of hyaluronan, a constituent of the extracellular matrix (ECM), hyaluronidase lowers the viscosity of hyaluronan, thereby increasing tissue permeability. In addition, bacterial hyaluronate lyases ( EC 4.2.2.1) may also be referred to as hyaluronidases, although this is uncommon.

The term hyaluronidase may also refer to hyaluronoglucuronidases ( EC 3.2.1.36), which cleave (1->3)-linkages. they cleave the (1->4)-linkages between N-acetylglucosamine and glucuronate. Īccording to their enzymatic mechanism, hyaluronidases are hyaluronoglucosidases ( EC 3.2.1.35), i.e. The resulting HA fragments of variable size are then further hydrolized by HYAL1 after being internalized into endo- lysosomes this generates HA oligosaccharides. GPI-anchored HYAL2 is responsible for cleaving high-molecular weight HA, which is mostly bound to the CD44 receptor. HYAL1 and HYAL2 are the major hyaluronidases in most tissues. The genes for HYAL1-3 are clustered in chromosome 3, while HYAL4-6 are clustered in chromosome 7.

Hyaluronidase vs vtrace plus#

In humans, there are five functional hyaluronidases: HYAL1, HYAL2, HYA元, HYAL4 and HYAL5 (also known as SPAM1 or PH-20) plus a pseudogene, HYAL6 (also known as HYALP1). The three main types of hyaluronidases are two classes of eukaryotic endoglycosidase hydrolases and a prokaryotic lyase-type of glycosidase. Karl Meyer classified these enzymes in 1971, into three distinct groups, a scheme based on the enzyme reaction products. A 10-year experience with 150 cases.Hyaluronidases are a family of enzymes that catalyse the degradation of hyaluronic acid (HA).

Clinical evaluation of different treatment methods for oral submucous fibrosis.

Hyaluronidase vs vtrace trial#

A randomized double-blind, multiple-arm trial comparing the efficacy of submucosal injections of hyaluronidase, dexamethasone, and combination of dexamethasone and hyaluronidase in the management of oral submucous fibrosis.

Evaluation of efficacy of aloe vera in the treatment of oral submucous fibrosis - a clinical study.

A comparative study of various modalities in the treatment of keloids.

Betamethasone oral mini-pulse therapy compared with topical triamcinolone acetonide (0.1%) paste in oral lichen planus: A randomized comparative study.

Efficacy of oral colchicine with intralesional hyaluronidase or triamcinolone acetonide in the Grade II oral submucous fibrosis.

Pentoxifylline therapy in the management of oral submucous fibrosis.

Isolated corymbose collagenoma responding to intralesional triamcinolone acetonide and hyaluronidase injections.

Comparison of Efficacy of Topical Curcumin Gel with Triamcinolone-hyaluronidase Gel Individually and in Combination in the Treatment of Oral Submucous Fibrosis.

Randomized trial of pimecrolimus cream versus triamcinolone acetonide paste in the treatment of oral lichen planus.

A follow up study is required to see long term effects. INTERPRETATION & CONCLUSION: Treatment regimen of group B was more convenient to the patients because less number of visits required and cheap. RESULTS: No statistically significant difference in symptom score, sign score and histopathological improvement was seen between the two groups. Student's 't' test was applied for comparing the results. Treatment outcome was evaluated on the basis of improvement in symptom score, sign score and histopathological improvement. Group B patients received combination of triamcinolone acetonide (10 mg/ml)/ hyaluronidase (1500 IU) at 15 days interval for 22 wk.

Group A patients received combination of hydrocortisone acetate (1.5 ml)/hyaluronidase (1500 IU) at weekly interval submucosally in pterygomandibular raphe, half dose on each side for 22 wk. METHODS: Patients of OSMF (100) were randomly divided into two groups A and B. In this study we compared the efficacy of hydrocortisone acetate and hyaluronidase at weekly interval versus triamcinolone acetonide and hyaluronidase at 15 days interval. The problem with the prevailing treatment was injections at weekly interval. Its medical treatment is not yet fully standardized, although the optimal doses of its medical treatment is in the form of hydrocortisone acetate combined with hyaluronidase. N2 - BACKGROUND & OBJECTIVES: Oral submucous fibrosis is a common premalignant condition caused by chewing arecanut and other irritants in various forms. JF - The Indian journal of medical research T1 - Efficacy of hydrocortisone acetate/hyaluronidase vs triamcinolone acetonide/hyaluronidase in the treatment of oral submucous fibrosis.